Decoupling of oxygen transfer and power dissipation for the study of the production of pristinamycins by Streptomyces pristinaespiralis in shaking flasks
Identifieur interne : 000751 ( Main/Exploration ); précédent : 000750; suivant : 000752Decoupling of oxygen transfer and power dissipation for the study of the production of pristinamycins by Streptomyces pristinaespiralis in shaking flasks
Auteurs : Nasir Mehmood [France] ; Eric Olmos [France] ; Jean-Louis Goergen [France] ; Fabrice Blanchard [France] ; Philippe Marchal [France] ; W. Klöckner [Allemagne] ; J. Büchs [Allemagne] ; Stéphane Delaunay [France]Source :
- Biochemical Engineering Journal [ 1369-703X ] ; 2012-10-15.
English descriptors
- mix :
Abstract
Streptomyces pristinaespiralis is a filamentous bacterium used in the pharmaceutical industry for the production of pristinamycins. In previous works, it was shown that the occurrence of production and the antibiotics concentration could be related to gas-liquid transfer and power dissipation in shaking flasks. Nevertheless, in standard cultures, both mechanisms are coupled. It is then a difficult task to assign a precise physiological response to either oxygen transfer or power dissipation. The aim of the present study was to decouple the oxygen transfer coefficient (k(L)a) and the power dissipation per unit of volume (Ply) to study their respective impact on pristinamycin production. During cultures in flasks, the rotation diameter of the shaking table was changed to modify the k(L)a but not the power dissipation P/V. The influence of operating conditions with P/V ranging from 0.55 to 10.3 kW m(-3) and k(L)a ranging from 30 to 490 h(-1) have been determined on the microbial kinetics and also on the pellet diameters. The final biomass concentration and the release of antibiotics were then related to k(L)a, whereas the final pristinamycins concentrations, as well as the bacterial pellet diameter were mainly correlated to P/V independently of the k(L)a. The change in the pellet diameter could be the crucial parameter for the pristinamycins production as it might influence the nutriment transfer inside the pellets and the ratio of active cells in each pellet.
Url:
DOI: 10.1016/j.bej.2012.06.021
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Hal, to step Curation: 000289
- to stream Hal, to step Checkpoint: 000694
- to stream Main, to step Merge: 000808
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Le document en format XML
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ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine><country key="FR"></country></address><ref type="url">http://lrgp.univ-lorraine.fr/</ref></desc><listRelation><relation active="#struct-413289" type="direct"></relation><relation name="UMR7274" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno><idno type="IdUnivLorraine">[UL]100--</idno><orgName>Université de Lorraine</orgName><orgName type="acronym">UL</orgName><date type="start">2012-01-01</date><desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-lorraine.fr/</ref></desc></org></tutelle><tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Nancy</settlement><settlement type="city">Metz</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Marchal, Philippe" sort="Marchal, Philippe" uniqKey="Marchal P" first="Philippe" last="Marchal">Philippe Marchal</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno><idno type="RNSR">201320573K</idno><idno type="IdUnivLorraine">[UL]RQC--</idno><orgName>Laboratoire Réactions et Génie des Procédés</orgName><orgName type="acronym">LRGP</orgName><date type="start">2013-01-01</date><desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine><country key="FR"></country></address><ref type="url">http://lrgp.univ-lorraine.fr/</ref></desc><listRelation><relation active="#struct-413289" type="direct"></relation><relation name="UMR7274" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno><idno type="IdUnivLorraine">[UL]100--</idno><orgName>Université de Lorraine</orgName><orgName type="acronym">UL</orgName><date type="start">2012-01-01</date><desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-lorraine.fr/</ref></desc></org></tutelle><tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Nancy</settlement><settlement type="city">Metz</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Klockner, W" sort="Klockner, W" uniqKey="Klockner W" first="W." last="Klöckner">W. Klöckner</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211974" status="INCOMING"><orgName>AVT Biochem Engn</orgName><desc><address><addrLine>Rhein Westfal TH Aachen, AVT Biochem Engn, D-52056 Aachen</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-300797" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300797" type="direct"><org type="institution" xml:id="struct-300797" status="VALID"><orgName>Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Deutschland</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Buchs, J" sort="Buchs, J" uniqKey="Buchs J" first="J." last="Büchs">J. Büchs</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211974" status="INCOMING"><orgName>AVT Biochem Engn</orgName><desc><address><addrLine>Rhein Westfal TH Aachen, AVT Biochem Engn, D-52056 Aachen</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-300797" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300797" type="direct"><org type="institution" xml:id="struct-300797" status="VALID"><orgName>Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Deutschland</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Delaunay, Stephane" sort="Delaunay, Stephane" uniqKey="Delaunay S" first="Stéphane" last="Delaunay">Stéphane Delaunay</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno><idno type="RNSR">201320573K</idno><idno type="IdUnivLorraine">[UL]RQC--</idno><orgName>Laboratoire Réactions et Génie des Procédés</orgName><orgName type="acronym">LRGP</orgName><date type="start">2013-01-01</date><desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine><country key="FR"></country></address><ref type="url">http://lrgp.univ-lorraine.fr/</ref></desc><listRelation><relation active="#struct-413289" type="direct"></relation><relation name="UMR7274" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno><idno type="IdUnivLorraine">[UL]100--</idno><orgName>Université de Lorraine</orgName><orgName type="acronym">UL</orgName><date type="start">2012-01-01</date><desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-lorraine.fr/</ref></desc></org></tutelle><tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Nancy</settlement><settlement type="city">Metz</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></analytic><idno type="DOI">10.1016/j.bej.2012.06.021</idno><series><title level="j">Biochemical Engineering Journal</title><idno type="ISSN">1369-703X</idno><imprint><date type="datePub">2012-10-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>ANTIBIOTIC PRODUCTION</term><term>ASPERGILLUS-NIGER</term><term>BATCH CULTURE</term><term>DISSOLVED-OXYGEN</term><term>FUNGAL MORPHOLOGY</term><term>GROWTH</term><term>Gas-liquid mass transfer coefficient</term><term>IN-VITRO ACTIVITY</term><term>MECHANICAL FORCES</term><term>PENICILLIUM-CHRYSOGENUM</term><term>Power dissipation</term><term>Pristinamycins</term><term>SUBMERGED FERMENTATION</term><term>Shaking flask</term><term>Streptomyces</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Streptomyces pristinaespiralis is a filamentous bacterium used in the pharmaceutical industry for the production of pristinamycins. In previous works, it was shown that the occurrence of production and the antibiotics concentration could be related to gas-liquid transfer and power dissipation in shaking flasks. Nevertheless, in standard cultures, both mechanisms are coupled. It is then a difficult task to assign a precise physiological response to either oxygen transfer or power dissipation. The aim of the present study was to decouple the oxygen transfer coefficient (k(L)a) and the power dissipation per unit of volume (Ply) to study their respective impact on pristinamycin production. During cultures in flasks, the rotation diameter of the shaking table was changed to modify the k(L)a but not the power dissipation P/V. The influence of operating conditions with P/V ranging from 0.55 to 10.3 kW m(-3) and k(L)a ranging from 30 to 490 h(-1) have been determined on the microbial kinetics and also on the pellet diameters. The final biomass concentration and the release of antibiotics were then related to k(L)a, whereas the final pristinamycins concentrations, as well as the bacterial pellet diameter were mainly correlated to P/V independently of the k(L)a. The change in the pellet diameter could be the crucial parameter for the pristinamycins production as it might influence the nutriment transfer inside the pellets and the ratio of active cells in each pellet.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Metz</li><li>Nancy</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Mehmood, Nasir" sort="Mehmood, Nasir" uniqKey="Mehmood N" first="Nasir" last="Mehmood">Nasir Mehmood</name></region><name sortKey="Blanchard, Fabrice" sort="Blanchard, Fabrice" uniqKey="Blanchard F" first="Fabrice" last="Blanchard">Fabrice Blanchard</name><name sortKey="Delaunay, Stephane" sort="Delaunay, Stephane" uniqKey="Delaunay S" first="Stéphane" last="Delaunay">Stéphane Delaunay</name><name sortKey="Goergen, Jean Louis" sort="Goergen, Jean Louis" uniqKey="Goergen J" first="Jean-Louis" last="Goergen">Jean-Louis Goergen</name><name sortKey="Marchal, Philippe" sort="Marchal, Philippe" uniqKey="Marchal P" first="Philippe" last="Marchal">Philippe Marchal</name><name sortKey="Olmos, Eric" sort="Olmos, Eric" uniqKey="Olmos E" first="Eric" last="Olmos">Eric Olmos</name></country><country name="Allemagne"><noRegion><name sortKey="Klockner, W" sort="Klockner, W" uniqKey="Klockner W" first="W." last="Klöckner">W. Klöckner</name></noRegion><name sortKey="Buchs, J" sort="Buchs, J" uniqKey="Buchs J" first="J." last="Büchs">J. Büchs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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